By: Kieron Edwards, Ph.D.

Sage Rediscovered

Sage, a traditional medicine used by Greek, Roman, Ayurvedic, Native American and Chinese cultures, is undergoing more westernized scientific scrutiny.

Across the world, people are driven to become healthier, with an increased focus on wellness. According to Nielsen, the four macro-environmental trends that contribute to this are: an aging population; rising disease rates; increased interest in self-care, treatment and prevention; and the expansion of the educated and connected consumer.

The information age has bestowed a universal understanding about health issues, such as the opioids epidemic, and many people are becoming proactive and moving toward a more natural, traditional approach for their health care routines. In fact, the number of U.S. adults using dietary supplements increased 10 percent over the past decade, according to a consumer survey commissioned by the Council for Responsible Nutrition (CRN), and U.S. herbal supplements sales rose 8.5 percent in 2017, topping in at just over US$8 billion, according to the HerbalGram, published by the American Botanical Council (ABC).

Sage in all shapes

Sage is a perennial round shrub cultivated in different European countries, and the major phytochemicals in the flowers, leaves and stem are well identified. Sage leaves can be chewed whole, dried and ground into a powder; prepared as a fluid extract, tincture, or essential oil; or pressed fresh for the juice, according to HerbalGram. However, the leaf is the primary part of the plant used in most herbal preparations of sage. The phytochemical profile and phytotherapy will depend on how the Salvia species is prepared, where it is grown, and when it is harvested. As with all herbs, it is crucial that the source and preparation of the Salvia are consistent with the supporting clinical data to ensure a high level of effectiveness.

In a study by Moss et al. (2010), the cognitive and mood effects of aromatherapy using essential oils from two sage species (officinalis and lavandulafolia) were measured. While some results of the essential oil aromas matched some of those seen with orally administered herbal preparations of the same species, the range of benefits were not as broad as the oral preparations.

Making it mainstream

Herbal supplementation has not always had the data or regulatory support to make it to the mainstream user, and as people demand more information on what they consume, they also insist on proven efficacy. Meaning, the traditional use for an ingredient must be supported by current clinical or pre-clinical data. Recent investigative studies have been conducted to document the conventional use of sage and find new biological effects of this plant.

The 900 species of Salvia make it the largest genus of the Lamiaceae family.6 Of these, three—Salvia officinalis, S. lavandulaefolia and S. miltiorrhiza—are particularly notable for their reputed beneficial effects on behavioral function including depression, memory disorders and age-related memory decline.

Specifically, studies conducted with extracts of S. officinalis demonstrated a pronounced effect on cognitive performance in both healthy young adults12 those 65 years and older. The dose-response study had a clear benefit in key cognitive performance (working memory, secondary memory and accuracy of attention) in as early as one hour of administering the proprietary sage extract.

Healthy aging has quickly become a concern for all generations, and the term overwhelmingly refers to maintaining cognitive and physical health, according to Nielsen. Traditionally, cognitive well-being may have been perceived as a concern for our senior years, however, over the past 12 years, the importance of cognitive function among all generations has grown more than 20 percent among American consumers, according to the Natural Marketing Institute (NMI). In addition, the number of people over the age of 60 is expected to double by 2050, according to data from The World Health Organization (WHO). This means brands have a great opportunity to help consumers bridge the gap between living longer and living healthier. With the advancements of clinical data, CPG brand owners have the chance to prove that natural healing remedies can be a solution to help improve health care for all generations.

Kieron Edwards, Ph.D., scientific director at Sibelius Natural Products, obtained a doctorate in plant genetics at the University of Warwick, and then gained over 10 years’ experience in biological research in both an academic and industrial setting, most recently with Advanced Technologies Cambridge Ltd., including its subsequent merger into British American Tobacco. Over this time, he used genetic, genomic, transcriptomic, metabolomic and other systems approaches to investigate the regulation of physiological and biochemical traits in plants to support both fundamental understanding and trait development. In addition to his scientific training, Edwards completed his master of business administration at the University of Cambridge Judge Business school in 2016.

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